Ozempic, the widely discussed semaglutide, is gaining attention for reasons beyond weight management. Recent research suggests that its advantages may also encompass various health concerns, with studies currently investigating its impact on conditions related to dementia, osteoarthritis, and kidney function.

How much of this is fact, and how much is fiction? As a coach, investing time in knowing what’s supported by scientific research rather than speculation is critical. 

We will explore the evidence supporting Ozempic’s possible impact on managing conditions such as osteoarthritis, kidney health, and dementia. This will enable you to modify your clients’ routines and recognize when collaboration with their healthcare provider is necessary.

Ozempic and Osteoarthritis

Does Ozempic really work for osteoarthritis pain? For many clients over 45, osteoarthritis is more common than we’d like. If obesity is part of the picture, that extra weight strains their knees, leading to pain and inflammation. Here’s where Ozempic comes in: it can help with weight management and, by extension, relieve joint stress.

Research suggests that Ozempic’s weight loss effects significantly reduce knee stress, lessen pain, and improve mobility. In one study, participants lost an average of 13.7% of their body weight, which correlated with notable pain reduction. Ozempic users reported a significant 41.7-point drop in knee pain scores, almost double the relief in placebo patients. 

And it’s not just about weight loss; experts think its anti-inflammatory effects are also doing some heavy lifting.

Ozempic Effects on Kidney Health

Let’s talk kidneys. For clients with obesity or diabetes, the risk of chronic kidney disease (CKD) looms large. Ozempic might step in, helping to prevent damage before symptoms even show up.

Does Ozempic work for kidney health? Studies show that Ozempic lowers protein levels in urine, a marker of kidney damage, and lowers inflammation and blood pressure. These effects contribute to improved kidney function in those with or without diabetes.

In a 24-week study, Ozempic users exhibited a 52% reduction in urinary protein levels, alongside weight loss and lowered blood pressure. The results suggest that it may delay CKD progression, though its direct use for kidney disease is pending FDA approval.

Ozempic and Dementia

There’s growing interest in whether Ozempic can support brain health, particularly for dementia and Alzheimer’s disease. Obesity and diabetes are risk factors due to vascular damage and chronic inflammation, but weight management may help.

Does Ozempic work to help lower the risk of dementia? Here’s a surprise: research suggests that Ozempic could reduce Alzheimer’s risk in diabetes patients by up to 70%. Scientists point to its anti-inflammatory properties and improved vascular function as possible reasons. While ongoing trials aim to confirm these results, the current evidence suggests that Ozempic’s weight loss and inflammation reduction could benefit clients concerned about cognitive health.

Ozempic and Heart Health

Can Ozempic protect heart health? With obesity and diabetes linked to inflammation and blood vessel damage, Ozempic claims to reduce cardiovascular risks by addressing these underlying issues.

Does Ozempic work on heart health? One clinical trial on Ozempic revealed an 18% drop in cardiovascular events, a number that’s hard to ignore. It is due to Ozempic’s ability to lower blood pressure, stabilize glucose, and promote weight loss, all of which contribute to a healthier heart.

If you coach clients dealing with obesity-related heart concerns, this medication might be a game-changer in their journey. Pairing Ozempic with a structured fitness routine and a client-focused meal plan could reduce these risks. 

Final Thoughts

Ozempic offers advantages that extend well beyond its initial use, potentially providing your clients with optimism in managing issues such as osteoarthritis, kidney function, and even dementia. As a coach, a comprehensive understanding of these medications and the underlying science of their mechanisms and impacts can transform how you assist your clients on their journey. 

When working with clients using Ozempic, it’s essential to remember that medication works best as part of a comprehensive approach to health. By combining medication management with targeted exercise programming, proper nutrition, and regular health monitoring, you can help your clients achieve optimal results. Stay informed about the latest research and communicate openly with their healthcare providers to ensure the best possible outcomes. 

References

• Bliddal H, Bays H, Czernichow S, et al. Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis. N Engl J Med. 2024;391(17):1573-1583. doi:10.1056/NEJMoa2403664
• Apperloo EM, Gorriz JL, Soler MJ, et al. Semaglutide in patients with overweight or obesity and chronic kidney disease without diabetes: a randomiz,ed double-blind placebo-controlled clinical trial. Nat Med. Published online October 25, 2024. doi:10.1038/s41591-024-03327-6
• Wang W, Wang Q, Qi X, et al. Associations of semaglutide with first-time diagnosis of Alzheimer’s disease in patients with type 2 diabetes: Target trial emulation using nationwide real-world data in the US. Alzheimers Dement. Published online October 24, 2024. doi:10.1002/alz.14313
• Perkovic V, Tuttle KR, Rossing P, et al. Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes. N Engl J Med. 2024;391(2):109-121. doi:10.1056/NEJMoa2403347
• Cheatham S, Davila E, Dieter B, Bustillo E, Fantigrassi M, Sutton B. GLP-1 Medication: An Evidence-Based Review. © National Academy of Sports Medicine; 2023. Available at: https://www.nasm.org/docs/nasmlibraries/pdf/glp1_medication_evidence-based_review_final-medical-10-19-23.pdf. Accessed November 18, 2024.

About Robert James Rivera
Robert is a full-time freelance writer and editor specializing in the health niche and its ever-expanding sub-niches. As a food and nutrition scientist, he knows where to find the resources necessary to verify health claims.